Coombs Negative Autoimmune Hemolytic Anemia in Crohn’s Disease

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Coombs-Negative Autoimmune Hemolytic Anemia in Crohn’s Disease

BACKGROUND Anemia is a common, important extraintestinal complication of Crohn's disease. The main types of anemia in patients with Crohn's disease are iron deficiency anemia and anemia of chronic disease. Although patients with Crohn's disease may experience various type of anemia, autoimmune hemolytic anemia (AIHA) in patients with Crohn's disease, especially Coombs-negative AIHA, is very rar...

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Direct antiglobulin ("Coombs") test-negative autoimmune hemolytic anemia: a review.

We have reviewed the literature to identify and characterize reports of warm-antibody type, autoimmune hemolytic anemia in which the standard direct antiglobulin reaction was negative but a confirmatory test indicated that the red cells were opsonized with antibody. Three principal reasons account for the absence of a positive direct antiglobulin test in these cases: a) IgG sensitization below ...

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We report on a patient affected by multicentric Castleman's disease who developed an acute immunohemolytic anemia due to warm antibody. The clinical course was characterized by refractoriness to the steroidal treatment and by a dramatic improvement of the hematological and objective picture following combination chemotherapy (CHOP regimen). The possible existence of a link between the lymphopro...

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ژورنال

عنوان ژورنال: American Journal of Case Reports

سال: 2014

ISSN: 1941-5923

DOI: 10.12659/ajcr.892136